A compendium of next-generation patient-derived models for diverse cancers
Nature
Medical/Healthcare AI
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E. Francies, Dennis Plenker, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, Rachana Agarwal, Jean Claude Zenklusen, James M. Clinton, Jennifer M. Shelton, Timothy R. Chu, William F. Hooper, Xavi Loinaz, Paula Keskula, Jordan Tagle, Peyton C. Kuhlers, Bahar Tercan, Sylvia F. Boj, Alessandro Vasciaveo, Lorenzo Tomassoni, James M. Crawford, Shawna Walsh, Claire Sinai, Sonam Bhatia, Priya Sridevi, Hardik Patel, Maria Antonietta Cerone, Mubarak Akadri, Andrew J. Aguirre, Rehan Akbani, Majd Al Assaad, Wael Al Zoughbi, Alyaa Al-Ibraheemi, Sahar Alkhairy, Nasser Altorki, Silvia Andreani, Joshua Araya, Gayatri Arun, Adel Atari, Stefanie Avril, Toby M. Baker, Metin Balaban, Michael Barnes, Caitlyn W. Barrett, Adam Bass, Alexandra E. Beck, Pascal Belleau, Christopher C. Benz, Bhavneet Bhinder, Shriram G. Bhosle, Julie Boerner, Jay Bowen, Lauren Brais, Bradley M. Broom, Catherine A. Bullen, Jonathan M. Buscaglia, Thomas Anthony Caiazza, Joshua D. Campbell, Evelyn Cantillo, Song Cao, Jared A. Capuano, Mauro A. A. Castro, Eloise Chapman-Davis, Kami Chiotti, Toni K. Choueiri, Kin-Hoe Chow, Wolu Chukwu, Alanna J. Church, Hans Clevers, Catherine Clinton, Isidro Cortes-Ciriano, Daniel B. Costa, Gregory M. Cote, Brian D. Crompton, Sabrina D’Agosto, Simona Dalin, Melissa Davis, Frederik De Smet, Rebecca Deasy, Mimoun Delmar, Paula I. Denoya, Astrid Deschênes, Li Ding, Elizabeth R. Duffy, Ruvimbo Dzvurumi, Kenneth Eng, Jose Espejo Valle-Inclan, Bishoy M. Faltas, Michelle Feenstra, Idhaliz Flores, Sharon B. Fox, Melissa K. Frey, Marina Frimer, Jack Geduldig, Veerle Geurts, Gad Getz, James G. R. Gilbert, Gary L. Goldberg, Sara Goodwin, Peter K. Gregersen, Evan Grossman, Akansha A. Gupta, Amber N. Habowski, William C. Hahn, Peter Hammerman, D. Neil Hayes, David I. Heiman, Elizabeth P. Henske, Carmen Herranz-Ors, Julian M. Hess, Kevin Holcomb, Andrew L. Hong, Christine Hudson, Victoria Hung, Lora Iliev, Katherine A. Janeway, Julia O. Japo, Grace Johnson, Jihang Ju, Troy J. Kane, Samuel J. Klempner, Melissa Kramer, Anneke Kramm, Alexander Krasnitz, Shwetha V. Kumar, Rita Teresa Lawlor, Gwo-Shu Mary Lee, Siyun Lee, Hongyu Li, Ellen Li, Madison Liistro, Jochen Lorch, Carolina Lucchesi, Claudio Luchini, Seth Malinowski, Jyothi Manohar, Laura A. Martello, Jennifer L. Marti, M. Laura Martin, R. Jay Mashl, W. Richard McCombie, Aaron K. McCormick, Brian W. McSteen, Christine N. Metz, Ana Molina, Juan Miguel Mosquera, Jenna E. Moyer, Anthony Murphy, Payal Naik, Indu Nair, David M. Nanus, Emon Nasajpour, Jones T. Nauseef, Lisa Newman, Kimmie Ng, Samuel Y. Ng, Allyson Ocean, Coyin Oh, Kentaro Ohara, Kadir Ozler, Kila Panchot, Nicole Pavao, Antonio Pea, Kristine Pelton, Anson Peng, Claudia K. Petritsch, Payal Pradhan, Sidharth V. Puram, Meifang Qi, Srivatsan Raghavan, Benjamin J. Raphael, David Requena, Phoebe L. Reuben, Esther Rheinbay, Arvind Rishi, Carmen Rios, A. Gordon Robertson, Peter Ronning, Ashley R. Ruehr, Suzanne Russo, Andrea Ruzzenente, Michael Ryan, Roberto Salvia, David Sandak, Shahab Sarmashghi, Ashish Saxena, Abeer Sayeed, Parul Shukla, Andrea Sboner, Aldo Scarpa, Douglas S. Scherr, Francesco Serafini, Hui Shen, Aniket Shetty, Manish Shah, Ewa Sicinska, Sabina Signoretti, Michael Sigouros, Amber R. Smith, Yizhe Song, Yingduo Song, Conrado T. Soria, Cora Sternberg, Joshua M. Stuart, Cheryl L. Thompson, Natalie Tsang, Aviad Tsherniak, Cristina Valente, Sara Valentini, Johan H. van Es, Barbara Van Hare, Shivakumar Vignesh, Jayne Vogelzang, Abigail Ward, Fiona Watkinson, Sophie Webster, John N. Weinstein, David M. Weinstock, Michael C. Wendl, Brian M. Wolpin, Christopher K. Wong, Maoxin Wu, Matthew A. Wyczalkowski, William P. Wysocki, Alexa Yeagley, Smitha Yerrum, Charles H. Yoon, Jenny Yuan, Brian Yueh, Zhenyu Zhang, Kyle Ellrott, Calvin J. Kuo, Olivier Elemento, Semir Beyaz, Vincenzo Corbo, David L. Spector, Rameen Beroukhim, Martin L. Ferguson, Andrew D. Cherniack, Peter W. Laird, Nicolas Robine, Andrew McPherson, Katherine A. Hoadley, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse S. Boehm
2026-08-05
TL;DR - The Human Cancer Models Initiative presents a large resource of next-generation patient-derived cancer models, spanning 2,780 donors and 25 cancer types. It enables comparative cancer research through integrated molecular characterization of tumors and their corresponding models.
- Covers patient-derived models from 2,780 cancer donors.
- Represents 25 distinct cancer types.
- Integrates tumor–model genomic, transcriptomic, and epigenomic analyses.
- Provides a standardized resource for studying cancer diversity and model fidelity.