Switching off the FNIP1 gene protects against metabolic disease

TL;DR - Rare FNIP1-disrupting variants are linked to healthier metabolic profiles and about 60% lower cardiometabolic disease risk. Mouse experiments suggest that suppressing the FNIP1 pathway could reproduce these protective effects.

• The human analysis included more than one million people.
• Rare FNIP1 variants were associated with favorable metabolic traits.
• Silencing pathway genes in mice increased fat breakdown.
• The findings identify FNIP1 signaling as a potential metabolic-disease target.