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Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours

Nature Neuroscience Sara G. Pelaz, Katsukuni Mitsui, Natalia Kolosowska, Haley Fritch, Chiranjivi Neupane, Vanessa H. Casha, Marta Alonso-GardĂłn, Vijaya Pandey, Lizheng Wang, Riki Kawaguchi, James A. Wohlschlegel, Jiami Guo, Steven A. McCarroll, Sabina Berretta, Baljit S. Khakh 2026-08-05

TL;DR - A Nature paper reporting that primary cilia on astrocytes in the amygdala are disrupted by stress in mice, and that restoring them improves stress-related behaviour. Note: this is basic neuroscience, not AI research — only the title and a one-line abstract blurb were available, so takeaways are limited to what those state.

  • Identifies amygdala astrocytes (not neurons) and their primary cilia — the solitary signalling organelle — as a locus of stress-induced change.
  • Reports that stress disrupts these astrocyte primary cilia, implying a structural/signalling mechanism rather than purely synaptic plasticity.
  • Restoration of the cilia reportedly improves stress-related behaviour in mice, suggesting a causal, potentially reversible role.
  • No methods, effect sizes, cilia-signalling pathways, or stress-paradigm details are given in the provided content; the full article would be needed to assess evidence strength.

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