Cell子刊：北医三院李蓉/周平/于洋/潘恒等揭示这种乳杆菌可改善生殖衰老

TL;DR - A Cell Host & Microbe paper from Peking University Third Hospital's reproductive medicine center shows that the beneficial vaginal/uterine commensal Lactobacillus gasseri and its exopolysaccharide (EPS) reverse age-related endometrial aging and restore implantation capacity in aged mice, positioning the EPS as a candidate postbiotic for reproductive aging. It matters because endometrial decline — not just oocyte quality — limits live birth rates in older women, and this offers a microbiome-based intervention target.

• A cross-sectional human cohort with clinical follow-up found age-associated endometrial microbiome remodeling: loss of the beneficial Lactobacillus-dominant state and an increased proportion of Lactobacillus iners, correlating with impaired endometrial receptivity and poorer embryo transfer outcomes.
• Functional screening of reproductive-tract isolates identified L. gasseri as having strong antioxidant, anti-inflammatory, and adhesion-related activity.
• In cell assays and aged mouse models, L. gasseri and its EPS reduced endometrial senescence and improved embryo implantation, acting at least partly through the Hippo–YAP signaling pathway.
• Note: this is a microbiome/reproductive-biology study with no AI/ML component described; it is categorized as Research (a peer-reviewed Cell-family paper) rather than Industry news despite the WeChat source.