乳腺癌特定脂肪细胞亚型调控免疫抑制微环境

TL;DR - A single-nucleus RNA-sequencing study identifies breast-cancer-specific adipocyte subtypes that interact with macrophages to create immunosuppressive niches. These subtype-dependent pathways correlate with recurrence and suggest new microenvironment-targeted therapies.

• Adi_LDLR and Pre_Adi_LDLR were enriched in hormone-receptor-positive/HER2+ tumors and linked to senescence, immune suppression, and extracellular-matrix remodeling.
• Pre_Adi_LGR4_TGFBR1 was concentrated in triple-negative breast cancer, with reduced lipid metabolism and increased proliferative, metastatic, and immunosuppressive signaling.
• LDLR and TGFBR1 signal intensity correlated positively with recurrence.
• Adipocyte–Macro_TREM2 communication involved distinct VEGFA-related or LGALS3/FN1-integrin pathways across breast cancer subtypes.