单细胞测序揭示2型糖尿病β细胞异常、原发性干燥综合征免疫谜团、助力急性髓系白血病精准诊疗 | 单细胞视角

TL;DR - This research roundup highlights how single-cell and multi-omic sequencing is resolving disease-specific cell states in diabetes, Sjögren’s syndrome, and acute myeloid leukemia (AML), with potential diagnostic and treatment applications.

• A 4-million-cell pancreatic atlas identified plastic acinar-like cells and a loss of HNF1A-high β cells in type 2 diabetes.
• In Sjögren’s syndrome, HERC6, IL15, CD58, and PTGS2 formed a candidate diagnostic signature, with macrophages emerging as a key immune hub.
• In AML, single-cell DNA, RNA, protein, and spatial profiling can map clonal evolution, distinguish residual leukemia from clonal hematopoiesis, and expose drug-resistant subpopulations.
• Clinical adoption remains constrained by cost, workflow complexity, technical errors, and limited standardization.