‹ back to 2026-08-17

PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology

Nature Methods Spatial Biology Hendrik A. Michel, Paige McCallum, Wenrui Wu, Huaying Qiu, Jia Le Lee, Shuli Luo, Chi Ngai Chan, Johanna Schaffenrath, Yao Yu Yeo, Stephanie Pei Tung Yiu, Yang Wang, Lindsay Parmelee, Hongbo Wang, Tania Pannellini, Melinda Burgess, Nourhan El Ahmar, Zoe Xiaozhu Zhang, Colm Keane, Tony Kiat Hon Lim, Sabina Signoretti, Sonia Victoria Del Rincon, Bo Zhao, David R. McIlwain, Yunhao Bai, Fei Chen, Roberto Chiarle, Sizun Jiang 2026-08-17

TL;DR - PASTA is a platform-agnostic tyramide–oligonucleotide signal-amplification method for multiplexed, multimodal spatial imaging. It could make spatial biology workflows more versatile across imaging platforms and measurement modalities.

Uses tyramide–oligonucleotide amplification to enhance imaging signals.
Supports multiplexed imaging across multiple modalities.
Designed to work independently of a specific imaging platform.
The provided abstract does not report quantitative performance or validation results.

view merged work →