Design and optimization of a kinase-controlled allosteric switch

TL;DR - This Nature Methods article introduces a phosphorylation-controlled allosteric switch that regulates target proteins in response to ERK kinase activity. It offers a potential tool for linking cellular signaling states to programmable protein behavior.

• Uses ERK-mediated phosphorylation as the control signal.
• Regulates target proteins through an engineered allosteric mechanism.
• Focuses on the design and optimization of the phospho-switch.
• Specific performance results are not provided in the supplied content.