RT by @ylecun: what is happening here: claude used existing open source tools and orchestrated them…

TL;DR - Claude orchestrated existing open-source tools to run a protein-binder design campaign, reportedly producing experimentally tested designs against 14 of 15 targets. The commentary argues this demonstrates valuable biological reasoning and workflow orchestration, but not standalone protein design by Claude.

• A human expert supplied a detailed protein-design prompt, after which Claude coordinated specialized tools across the workflow.
• Adaptyv Bio and Twist Bioscience independently built and tested the resulting protein designs.
• Open-source academic tools performed much of the underlying computational work and deserve explicit credit.
• These tools may fail on targets outside their training-data distribution, limiting how broadly the reported results can generalize.