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Spatial chromatin architecture and accessibility co-profiling of mammalian tissues

Nature Methods Bioinformatics AI Ping Wang, Juan Wang, Qixuan Wang, Mark W. Youngblood, Yang Cheng, Bo Tao, Josiah Hiu-Yuen Wong, Yu Luan, Shaojun Yu, Alok Swaroop, Khizar R. Nandoliya, Hinda Najem, Yihao Fu, Kathleen McCortney, Di Zhang, Yarui Diao, Amy B. Heimberger, Adam M. Sonabend, Craig M. Horbinski, Rong Fan, Feng Yue 2026-09-01

TL;DR - Spatial-ATAC-Hi-C is a method for jointly profiling chromatin accessibility and three-dimensional chromatin organization while preserving spatial information in mammalian tissues. It could help connect local tissue structure with gene-regulatory architecture in healthy and diseased samples.

Co-profiles chromatin accessibility and chromatin organization in spatially resolved tissue regions.
Demonstrated on mouse brain tissue and human glioblastoma and astrocytoma samples.
Enables investigation of how epigenomic state and 3D genome architecture vary across tissue environments.
The provided abstract does not specify resolution, throughput, or quantitative performance.

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