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A thermodynamically favoured molecular computer

Nature Molecular Computing Tristan Stérin, Abeer Eshra, Constantine Glen Evans, Janet Adio, Damien Woods 2026-09-16

TL;DR - A scaffolded DNA computer performs multiple types of computation while thermodynamically relaxing toward equilibrium. The approach could enable simpler, reusable, fast, robust, and scalable molecular computing.

  • Demonstrated 10 programs, including parity and multiplication.
  • Performed addition on 25-bit inputs.
  • Uses thermodynamically favored relaxation rather than computation driven away from equilibrium.
  • Shows one molecular-computing framework can support diverse computational tasks.

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