Cell子刊：重庆医科大学陈承志/邱景富/许商成合作揭示，母亲缺乏维生素B12加剧后代肥胖的新机制

TL;DR - A Cell Metabolism study finds that maternal vitamin B12 deficiency worsens diet-induced obesity in offspring by disrupting early-life gut colonization by Bifidobacterium pseudolongum. Restoring the bacterium or its acetate metabolite mitigated obesity and metabolic dysfunction.

• B12 deficiency impaired maternal glucose metabolism and reproductive outcomes.
• Reduced maternal B. pseudolongum limited its transfer to offspring during early lactation.
• Early supplementation with B. pseudolongum or acetate improved offspring obesity outcomes.
• Acetate acted through the Ffar2–Ehhadh pathway to promote fatty-acid oxidation.