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Control of ice thickness in cryo-EM via confinement

Nature Methods Cryo-EM Methods Liming Zheng, Jiling Song, Xiaole Zhao, Jiacong Cao, Jie Xu, Zhengni Wang, Chenhui Zhang, Weiyu Sun, Buhang Chen, Xiaoyin Gao, Haonan Liu, Junhao Yang, Yu Xu, Luzhao Sun, Zhaohe Dai, Xiaoding Wei, Nan Liu, Hailin Peng, Hong-Wei Wang 2026-09-25

TL;DR - This study investigates graphene reservoirs formed over perforated support films to precisely control ice thickness during cryo-EM sample preparation. Better thickness control could improve the consistency and quality of cryo-EM specimens.

Uses confinement within graphene reservoirs to regulate ice thickness.
Forms the reservoirs over perforated supporting films.
Targets a key sample-preparation variable that affects cryo-EM imaging.
The provided summary does not report quantitative performance or experimental results.

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