沙库巴曲缬沙坦降压，不能和这3种药联用！

TL;DR - A clinical medication guide explains sacubitril/valsartan’s antihypertensive benefits, dosing, contraindicated combinations, and safety considerations. It is especially relevant for hypertension complicated by heart failure or kidney disease.

• Sacubitril/valsartan is an ARNI that promotes natriuresis and vasodilation; it may lower systolic pressure 5–7 mmHg more than ARB monotherapy.
• It may be combined with calcium-channel blockers, beta-blockers, or diuretics, but not ACE inhibitors, other ARBs, or aliskiren.
• After stopping an ACE inhibitor, clinicians should wait at least 36 hours before initiating sacubitril/valsartan.
• Key risks include angioedema, hypotension, renal impairment, and hyperkalemia; pregnancy is a contraindication.