Structural basis of the RNA-editing cascade in trypanosome mitochondria

TL;DR - Cryo-electron microscopy reveals the architecture of the Trypanosoma brucei mitochondrial editosome. The structure clarifies how this molecular assembly edits mRNA by inserting and deleting uridine nucleotides.

• Resolves the organization of the mitochondrial editosome.
• Examines the cascade responsible for mitochondrial RNA editing.
• Provides a structural basis for uridine insertion and deletion in mRNA.
• Advances understanding of RNA maturation in trypanosome mitochondria.