‹ back to 2026-07-22

Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Nature Medical/Healthcare AI Alexander B. Afeyan, Adi Nagler, Chloe R. Tu, Gabriel Roberti De Oliveira, Berkay Simsek, Maxwell D. Seager, Nourhan El Ahmar, Haley E. Sax, Emma Lin, Amit Sud, Mehdi Borji, Cleo Forman, Sophia Liu, Patrick A. Ott, Toni K. Choueiri, Jennifer G. Abelin, Richard Burack, Shuqiang Li, Kenneth J. Livak, Svitlana Tyekucheva, Derin B. Keskin, Fei Chen, Michael B. Atkins, Jeremy M. Simon, Sabina Signoretti, Giacomo Oliveira, David A. Braun, Catherine J. Wu 2026-07-22

TL;DR - A Nature study finds that tertiary lymphoid structures in renal cell carcinoma harbour tumour-specific CD8+ T-cell clonotypes with stem-like progenitor traits. These structures may help preserve less terminally exhausted immune cells within tumours.

TLS-containing tumours are enriched for exhausted CD8+ T cells.
The enriched population includes tumour-specific T-cell clonotypes.
Some clonotypes show stem-like progenitor features and reduced terminal exhaustion.
The findings clarify how TLSs may support antitumour immune responses.

view merged work →