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Precise DNA base editing using AlphaFold3-based contact modelling

Nature Bioinformatics AI Haowei Meng, Zhixin Lei, Yongchang Yan, Liren Wang, Sihan Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang, Rongrong Liu, Gaohui Yang, Ruoyu Shen, Ruichu Gu, Xinyan Wang, Yiya Wang, Suiru Lu, Zhicong Lv, Bo He, Han Wen, Dali Li, Chengqi Yi 2026-07-22

TL;DR - ContactSeek uses AlphaFold3-based contact modelling to improve the precision of DNA base-editing tools. The provided summary does not include quantitative results or methodological details.

Applies protein-structure modelling to genome-editing tool design.
Focuses on precise DNA base editing.
Demonstrates a potential bridge between foundation models for biology and genome-engineering applications.

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