AI-redesigned starting points and outcomes enhance protein evolution

TL;DR - This Nature study presents a workflow that uses AI-redesigned proteins as starting points for enzyme evolution. These starting points yield improved properties compared with evolving natural proteins directly.

• AI redesign is applied before experimental protein evolution.
• The workflow jointly improves starting proteins and evolutionary outcomes.
• The reported comparison favors AI-redesigned starting points over natural proteins.
• The provided abstract does not specify the enzymes, properties, or improvement magnitudes.