Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design

TL;DR - AAMFM jointly models antibody sequences, structures, and antigen context to design antibodies for specific targets. It matters because antigen and epitope conditioning may improve the functional relevance of generated antibodies.

• Uses a cross-modal adapter to incorporate antigen interfaces and epitope annotations.
• Represents antibody-antigen interactions in a shared latent space.
• Applies Calibrated Direct Preference Optimization using structural-prior preference signals.
• The authors report state-of-the-art functional antibody design performance and provide open-source code.