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A versatile platform for two-photon neuronal population voltage imaging across cortical depths

Nature Methods Neuroimaging Jingkun Guo, Kevin Barber, M. Agustina Frechou, Sihao Lu, Jeff Demas, David Chen, Shuyuan Yang, Alex James McDonald, Michelle Ann Land, François St-Pierre, Alipasha Vaziri 2026-07-23

TL;DR - FlatMux is an optimized microscope platform for multiplexed two-photon voltage imaging of neuronal populations. Its flexible design supports varied imaging configurations across cortical depths in mice.

Uses genetically encoded voltage sensors to measure neuronal activity.
Supports large-field-of-view and deep-brain imaging.
Enables simultaneous two-plane imaging.
Demonstrated across multiple mouse-brain imaging scenarios.

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