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Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Nature Methods Bioinformatics AI Hengxin Liu, Yanhong Hong, Yao Santo Zhang, Liyuan Xi, Huiying Yan, Yuxuan Liu, Qianqian Yang, Xing Sun, Shouliang Guan, Zan Chen, Yu Feng, Tao Zeng, Juan Meng, Sha Liao, Nini Yuan, Zhen Liu, Chao Li, Zhiyong Liu, Lei Han, Zhiming Shen, Ao Chen, Yidi Sun, Yuliang Dong, Longqi Liu, Chengyu Li, Wu Wei 2026-07-24

TL;DR - Fullscope-seq combines Stereo-seq spatial transcriptomics with long-read sequencing to map full-length transcript isoforms at single-cell resolution. Demonstrated on macaque brain slices, it enables analysis of spatially and cell-type-specific isoform usage across large tissue areas.

Integrates spatial transcriptomics with long-read sequencing.
Resolves transcript isoforms at single-cell resolution.
Covers a large field of view in macaque brain tissue.
Reveals spatial and cell-type-specific transcript isoforms.

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