Nature子刊：莫然/顾臻合作开发免疫刺激性脂质凝胶植入物，增强癌症免疫治疗

TL;DR - Researchers developed an immunostimulatory lipogel implant that locally delivers two cancer drugs with distinct release profiles. In mouse models, it enhanced checkpoint immunotherapy against stem-like tumors and helped suppress metastasis and postoperative recurrence.

• The lyotropic liquid-crystal gel co-delivers all-trans retinoic acid and doxorubicin.
• Differential sustained release promotes immunogenic cell death in drug-resistant, cancer stem-like cells.
• Local implantation stimulates antitumor immunity and improves synergy with immune checkpoint inhibitors.
• The work was published in Nature Nanotechnology.