Nature子刊：细胞外囊泡的催化谱分析，全面揭示癌症代谢改变

TL;DR - A Nature Nanotechnology study introduces ACTIVE, a programmable nanotechnology platform that profiles extracellular-vesicle metabolites directly from patient biofluids, enabling minimally invasive mapping of cancer metabolism and prognosis stratification.

• ACTIVE uses engineered catalytic bio–abiotic nanohybrids to quantify low-abundance EV-associated metabolites.
• Its catalytic efficiency exceeded wild-type catalysts by more than 30-fold, while detection limits in native biofluids improved over 1,000-fold.
• The platform captured broad metabolite profiles and metabolic-conversion dynamics across EV subpopulations.
• Using 5 μL of native ascites, ACTIVE identified tumor-microenvironment metabolic reprogramming patterns associated with patient prognosis.