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Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Nature Other Cristina Simó, Alexander C. Vanover, Ricardo D’Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M. Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti, Patrícia M. R. Pereira 2026-07-15

TL;DR — This is a biomedical/chemistry paper on in vivo bioorthogonal "click" ligation of therapeutic antibodies to antibody–drug conjugates (ADCs) to boost antitumor activity in resistant tumors; it is not AI-advancement material, so none of the AI topics apply.

  • Reports a modular strategy that links clinically used therapeutic antibodies to ADCs directly in the body via bioorthogonal click chemistry.
  • Claims enhanced antitumor activity in heterogeneous and treatment-resistant tumors, aimed at reversing drug resistance.
  • Content is thin (title + abstract snippet only); no AI/ML methods, models, or computational results are described, hence "Other."

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