Diverse bacterial pattern recognition receptors sense the core phage proteome

TL;DR - A systematic study identifies diverse prokaryotic STAND NTPases as antiviral pattern-recognition receptors. These sensors detect core structural and replication proteins across bacteriophages, revealing broad bacterial immune surveillance.

• Prokaryotic STAND NTPases are related to animal and plant immune receptors.
• The identified receptors recognize many conserved phage proteins.
• Targets span both phage structure and replication machinery.
• The findings broaden understanding of bacterial antiviral defense mechanisms.