Enzymatic glycosylation and amidation reshapes polyene bioactivity

TL;DR - Researchers discovered biosynthetic pathways and unusual enzymes that add sugars and amide groups to polyene scaffolds, reshaping their bioactivity. The resulting polyenes may enable safer antifungal treatments produced through efficient fermentation.

• Identifies pathways to previously undescribed polyenes.
• Finds enzymes capable of adding additional sugars to polyene scaffolds.
• Describes clean, efficient fermentation routes for accessing these compounds.
• Highlights their potential for safe therapeutic use against fungal infections.