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MIRAGE: Multi-scale Lesion-Informed Representation with Auxiliary Guidance for MRI Contrast Enhancement

Research Medical/Healthcare AI

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Overall 76
Content 90
Popularity 44

Observed public metrics from 1 member.

Merged summary

TL;DR - MIRAGE synthesizes contrast-enhanced breast MRI from a pre-contrast slice using lesion-aware training supervision. It improves patient-specific lesion localization while exposing trade-offs between clinical utility and realistic image generation.

  • Uses a residual 2D U-Net with reconstruction, perceptual, asymmetric enhancement, auxiliary segmentation, and frozen nnU-Net guidance losses.
  • Ranks first on six of eight metrics across 301 multi-centre MAMA-SYNTH cases.
  • Outperforms pix2pix, conditional diffusion, and latent bridge-matching baselines in downstream lesion localization.
  • Generative baselines remain stronger on LPIPS or contrast classification, highlighting a fidelity–utility trade-off.

Sources (1)

MIRAGE: Multi-scale Lesion-Informed Representation with Auxiliary Guidance for MRI Contrast Enhancement

arXiv eess.IV Andrea Borghesi, Xin Wang, Jonas Teuwen, George Yiasemis 2026-07-21 arXiv:2607.19137
Public signals Hugging Face upvotes 0
Providers: Hugging Face · Upvotes 0 OpenAlex · N/A Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-08-21 14:38:56.361056 UTC

TL;DR - MIRAGE synthesizes contrast-enhanced breast MRI from a pre-contrast slice using lesion-aware training supervision. It improves patient-specific lesion localization while exposing trade-offs between clinical utility and realistic image generation.

  • Uses a residual 2D U-Net with reconstruction, perceptual, asymmetric enhancement, auxiliary segmentation, and frozen nnU-Net guidance losses.
  • Ranks first on six of eight metrics across 301 multi-centre MAMA-SYNTH cases.
  • Outperforms pix2pix, conditional diffusion, and latent bridge-matching baselines in downstream lesion localization.
  • Generative baselines remain stronger on LPIPS or contrast classification, highlighting a fidelity–utility trade-off.
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