Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
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TL;DR - Structural studies reveal how Crimean–Congo haemorrhagic fever virus polymerase synthesizes RNA and identify potential antiviral targets. The findings could guide the design of both nucleoside and non-nucleoside inhibitors.
- Characterizes the structural basis of CCHFV RNA synthesis.
- Identifies druggable sites within the viral polymerase.
- Supports structure-guided development of two major classes of antivirals.
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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
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TL;DR - Structural studies reveal how Crimean–Congo haemorrhagic fever virus polymerase synthesizes RNA and identify potential antiviral targets. The findings could guide the design of both nucleoside and non-nucleoside inhibitors.
- Characterizes the structural basis of CCHFV RNA synthesis.
- Identifies druggable sites within the viral polymerase.
- Supports structure-guided development of two major classes of antivirals.