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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Research Medical/Healthcare AI

Merged summary

TL;DR - Structural studies reveal how Crimean–Congo haemorrhagic fever virus polymerase synthesizes RNA and identify potential antiviral targets. The findings could guide the design of both nucleoside and non-nucleoside inhibitors.

  • Characterizes the structural basis of CCHFV RNA synthesis.
  • Identifies druggable sites within the viral polymerase.
  • Supports structure-guided development of two major classes of antivirals.

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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Nature Lu Xue, Jiacheng Gui, Hainei Pan, Fan Wu, Shenghua Gao, Wenhua Kuang, Tiancai Chang, Zimu Li, Binqian Zou, Heyu Zhao, Mei Li, Min Zhou, Hongyu Yuan, Lijun Rong, Peng Gong, Jun He, Zengqin Deng, Manli Wang, Peng Zhan, Xinwen Chen, Xiaoli Xiong 2026-07-22 doi:10.1038/s41586-026-10701-6

TL;DR - Structural studies reveal how Crimean–Congo haemorrhagic fever virus polymerase synthesizes RNA and identify potential antiviral targets. The findings could guide the design of both nucleoside and non-nucleoside inhibitors.

  • Characterizes the structural basis of CCHFV RNA synthesis.
  • Identifies druggable sites within the viral polymerase.
  • Supports structure-guided development of two major classes of antivirals.
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