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Fly neurons carry a molecular ‘timestamp’ that encodes their birth order

Research Single-Cell Genomics

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TL;DR - A single-cell gene-expression atlas mapped onto the fruit-fly nerve cord’s wiring diagram revealed a shared molecular code that records neurons’ birth order. This “timestamp” helps explain how developmental lineage shapes neuronal diversity.

  • Integrates single-cell gene-expression data with neural connectivity.
  • Identifies a gene-expression code shared across neurons.
  • The code preserves the order in which neurons arose from a parent cell.
  • Birth-order information contributes to neuronal diversification.

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Fly neurons carry a molecular ‘timestamp’ that encodes their birth order

Nature 2026-07-22 doi:10.1038/d41586-026-02240-x
Public signals OpenAlex citations 0 · Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-21 14:37:33.813322 UTC

TL;DR - A single-cell gene-expression atlas mapped onto the fruit-fly nerve cord’s wiring diagram revealed a shared molecular code that records neurons’ birth order. This “timestamp” helps explain how developmental lineage shapes neuronal diversity.

  • Integrates single-cell gene-expression data with neural connectivity.
  • Identifies a gene-expression code shared across neurons.
  • The code preserves the order in which neurons arose from a parent cell.
  • Birth-order information contributes to neuronal diversification.
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