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Agent-Guided Relational Concept Discovery: Toward Interpretable Surgical Margin Assessment

Research Medical/Healthcare AI

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TL;DR - Agent-Guided Concept Discovery interprets REIMS surgical-margin data by learning concepts without manual annotations and grounding them in biochemical knowledge. It improves cancer-classification performance and shows better intraoperative generalization.

  • A reasoning agent refines concept descriptions and weights them by diagnostic relevance.
  • A biochemical knowledge graph aligns learned concepts with known metabolic relationships.
  • The model improves balanced accuracy and sensitivity on skin and breast cancer datasets versus the baseline.
  • In one representative intraoperative case, it produces fewer false positives.

Sources (1)

Agent-Guided Relational Concept Discovery: Toward Interpretable Surgical Margin Assessment

arXiv cs.AI Nooshin Maghsoodi, Amoon Jamzad, Robert Policelli, Mohammad Farahmand, Dilakshan Srikanthan, Martin Kaufmann, Kevin Y. M. Ren, Shaila Merchant, Sonal Varma, Ross Walker, Doug McKay, John Rudan, Gabor Fichtinger, Parvin Mousavi 2026-07-23 arXiv:2607.21437
Public signals Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · N/A Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-17 09:56:02.146680 UTC

TL;DR - Agent-Guided Concept Discovery interprets REIMS surgical-margin data by learning concepts without manual annotations and grounding them in biochemical knowledge. It improves cancer-classification performance and shows better intraoperative generalization.

  • A reasoning agent refines concept descriptions and weights them by diagnostic relevance.
  • A biochemical knowledge graph aligns learned concepts with known metabolic relationships.
  • The model improves balanced accuracy and sensitivity on skin and breast cancer datasets versus the baseline.
  • In one representative intraoperative case, it produces fewer false positives.
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