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OrthKD: Extracting Generalized Clinical Knowledge from Heterogeneous Teachers for Lightweight Deployment

Research Medical/Healthcare AI

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Merged summary

TL;DR - OrthKD selectively distills complementary knowledge from heterogeneous teachers into a lightweight diabetic-retinopathy screening model, improving edge deployment and robustness under domain shift.

  • Uses full supervision from a stronger EfficientNet-B3 teacher but only feature-level supervision from a weaker Swin-Base teacher.
  • Orthogonal student projections encourage teacher-specific features to contribute complementary local and global evidence.
  • The 5.4M-parameter MobileNetV3 student achieves 0.885 QWK on EyePACS.
  • Zero-shot Messidor-2 performance rises from 0.507 to 0.728 QWK, alongside strong referral AUC and calibration.

Sources (1)

OrthKD: Extracting Generalized Clinical Knowledge from Heterogeneous Teachers for Lightweight Deployment

arXiv cs.LG Yi Xu, Cheng Chen, Mufan Cao 2026-07-28 arXiv:2607.25545
Public signals Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · N/A Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-28 14:34:22.959168 UTC

TL;DR - OrthKD selectively distills complementary knowledge from heterogeneous teachers into a lightweight diabetic-retinopathy screening model, improving edge deployment and robustness under domain shift.

  • Uses full supervision from a stronger EfficientNet-B3 teacher but only feature-level supervision from a weaker Swin-Base teacher.
  • Orthogonal student projections encourage teacher-specific features to contribute complementary local and global evidence.
  • The 5.4M-parameter MobileNetV3 student achieves 0.885 QWK on EyePACS.
  • Zero-shot Messidor-2 performance rises from 0.507 to 0.728 QWK, alongside strong referral AUC and calibration.
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