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Rational design of disordered proteins for sequence–function investigation

Research Protein Design

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TL;DR - GOOSE enables rational design and large-scale testing of intrinsically disordered protein region sequences. It supports systematic investigation of how sequence determines function.

  • Designs thousands of disordered protein region sequences for experimental testing.
  • Reveals distinct sequence-to-function relationships.
  • Provides a scalable framework for studying disordered protein biology.

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Rational design of disordered proteins for sequence–function investigation

Nature Kara Hunter, Trevor Brandt, Karina Guadalupe, Kavindu C. Kolamunna, Jeffrey M. Lotthammer, Nora M. Shamoon, Jessica K. Niblo, Brooke Nicholson, Lea M. Day, Alec Martinez, Alex S. Holehouse, Shahar Sukenik, Ryan J. Emenecker 2026-07-29 doi:10.1038/s41586-026-10849-1
Public signals OpenAlex citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-08-28 14:32:44.089293 UTC

TL;DR - GOOSE enables rational design and large-scale testing of intrinsically disordered protein region sequences. It supports systematic investigation of how sequence determines function.

  • Designs thousands of disordered protein region sequences for experimental testing.
  • Reveals distinct sequence-to-function relationships.
  • Provides a scalable framework for studying disordered protein biology.
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