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Intestinal stem cells count self-renewal divisions to switch multipotency

Research Stem Cell Biology

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TL;DR - Drosophila intestinal stem cells use an epigenetic division-counting mechanism to switch cell fate every ninth self-renewal division. This reveals how adult stem cells can schedule distinct differentiated cell types while maintaining multipotency.

  • Stem cells initially produce enterocytes, the intestine’s absorptive cells.
  • Every ninth division instead generates an enteroendocrine mother cell.
  • The fate switch is governed by an epigenetic mechanism that tracks prior divisions.
  • Division history therefore directly influences adult stem-cell output.

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Intestinal stem cells count self-renewal divisions to switch multipotency

Nature Dong Tong, Anqi Li, Quanquan Jiang, Qili Yuan, Xiaozhao Liu, Ximiao He, Jiejunyi Liang, Yunyun Han, Zheng Guo 2026-07-29 doi:10.1038/s41586-026-10814-y
Public signals OpenAlex citations 1
Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-08-28 14:32:14.334775 UTC

TL;DR - Drosophila intestinal stem cells use an epigenetic division-counting mechanism to switch cell fate every ninth self-renewal division. This reveals how adult stem cells can schedule distinct differentiated cell types while maintaining multipotency.

  • Stem cells initially produce enterocytes, the intestine’s absorptive cells.
  • Every ninth division instead generates an enteroendocrine mother cell.
  • The fate switch is governed by an epigenetic mechanism that tracks prior divisions.
  • Division history therefore directly influences adult stem-cell output.
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