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A light-controlled tetanus neurotoxin enables rapid and reversible synaptic inhibition in vivo

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TL;DR - Researchers developed a light-controlled tetanus neurotoxin that rapidly and reversibly inhibits synaptic transmission in vivo. The tool enables precise manipulation of neural activity and mouse behavior beyond previous methods.

  • The engineered protease cleaves VAMP2, blocking synaptic vesicle fusion and neurotransmitter release.
  • Light provides temporal control over synaptic inhibition.
  • The method modulates both cellular activity and mouse behavior.
  • It may enable new mechanistic studies of neural circuits.

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A light-controlled tetanus neurotoxin enables rapid and reversible synaptic inhibition in vivo

Nature Methods 2026-07-30 doi:10.1038/s41592-026-03175-x
Public signals OpenAlex citations 0 · Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-28 14:31:29.610124 UTC

TL;DR - Researchers developed a light-controlled tetanus neurotoxin that rapidly and reversibly inhibits synaptic transmission in vivo. The tool enables precise manipulation of neural activity and mouse behavior beyond previous methods.

  • The engineered protease cleaves VAMP2, blocking synaptic vesicle fusion and neurotransmitter release.
  • Light provides temporal control over synaptic inhibition.
  • The method modulates both cellular activity and mouse behavior.
  • It may enable new mechanistic studies of neural circuits.
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