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Somatic mutations reveal the ontogeny of microglia in human aging

Research Medical/Healthcare AI

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TL;DR - A Nature study uses somatic mutations to investigate the developmental origins and aging of human microglia. Only the title and publication metadata are provided, so specific findings cannot be determined.

  • Published online in Nature on 30 July 2026.
  • Focuses on microglia, the brain’s resident immune cells.
  • Uses somatic mutations as lineage markers to study microglial ontogeny during human aging.
  • The supplied content does not report methods, cohort details, or results.

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Somatic mutations reveal the ontogeny of microglia in human aging

Nature Julia A. Belk, Yaowen Zhang, Emily E. Reilly, Quanming Shi, Daniel Dan Liu, Nicole Womack-Gambrel, Maarten van der Linde, Lisa Ma, Debasmita Paul, Alejandro Medina Enciso, Raja Kalluru, Jacob Weiss, Rui Li, Anna E. Eastman, Chunfang Zhu, Arnav Chakravarthy, Syed Bukhari, Dipabarna Bhattacharya, Suyash Raj, Daniel Richard, Simone Brioschi, Matthew R. Chrostek, Daniel C. Nachun, Christopher M. Arends, Jayakrishnan Gopakumar, Isak W. Tengesdal, Ademar Bynum, Shaneice Mitchell, Katalin Sandor, Wenxi Zhang, Badri N. Vardarajan, Inma Cobos, Donald E. Born, Robert B. West, Anne Brunet, Marco Colonna, Krishna L. Bharani, Hannes Vogel, Thomas J. Montine, Caitlin S. Latimer, Irving L. Weissman, Magdalena Matusiak, Jody E. Hooper, C. Dirk Keene, Howard Y. Chang, Siddhartha Jaiswal 2026-07-30 doi:10.1038/s41586-026-10939-0
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TL;DR - A Nature study uses somatic mutations to investigate the developmental origins and aging of human microglia. Only the title and publication metadata are provided, so specific findings cannot be determined.

  • Published online in Nature on 30 July 2026.
  • Focuses on microglia, the brain’s resident immune cells.
  • Uses somatic mutations as lineage markers to study microglial ontogeny during human aging.
  • The supplied content does not report methods, cohort details, or results.
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