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SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

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TL;DR - SeekBrain is an autonomous multi-agent framework that uses domain-grounded hierarchical planning to generate hypotheses and analysis pipelines for heterogeneous, multi-scale neuroscience data. It matters because fragmented workflows and data heterogeneity are a key bottleneck in neuroscience, and the system shows agents can produce real scientific findings, not just benchmark scores.

  • Builds a repertoire of reusable "analysis recipes" mined from code-paper pairs, coupling codified domain expertise with agentic planning and execution engines.
  • Evaluated on BrainArena, an expert-annotated benchmark, where it reportedly outperforms state-of-the-art agent baselines across a range of analysis tasks.
  • Deployed in real research: integrated behavioral, neural, and anatomical data to reveal structured distributed neural representations of larval zebrafish behavior, plus a shared axis of regional decoding strength in a mouse decision-making task.
  • Emphasis on cross-modal, multi-scale data integration and on-demand pipeline generation rather than fixed, hand-built analysis workflows.

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SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

arXiv cs.MA Jiamin Wu, Peishan Xiang, Jingyang Chen, Yuqing Zhu, Yuxi Li, Ling Luo, Qihao Zheng, Jialiang Zu, Yongchao Wu, Mindong Liu, Haitao Wu, Chaofan Hu, Yijie Sun, Yuqi Hang, Yu Zhu, Shuo Li, Yue Fan, Shiyang Feng, Wanghan Xu, Tianlei Zhang, Jie Zhang, Wenlong Zhang, Bo Zhang, Kai Wang, Lei Bai, Mianxin Liu, Wanli Ouyang, Jiulin Du, Chunfeng Song 2026-07-31 arXiv:2607.29347
Public signals Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · N/A Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-24 14:28:52.429242 UTC

TL;DR - SeekBrain is an autonomous multi-agent framework that uses domain-grounded hierarchical planning to generate hypotheses and analysis pipelines for heterogeneous, multi-scale neuroscience data. It matters because fragmented workflows and data heterogeneity are a key bottleneck in neuroscience, and the system shows agents can produce real scientific findings, not just benchmark scores.

  • Builds a repertoire of reusable "analysis recipes" mined from code-paper pairs, coupling codified domain expertise with agentic planning and execution engines.
  • Evaluated on BrainArena, an expert-annotated benchmark, where it reportedly outperforms state-of-the-art agent baselines across a range of analysis tasks.
  • Deployed in real research: integrated behavioral, neural, and anatomical data to reveal structured distributed neural representations of larval zebrafish behavior, plus a shared axis of regional decoding strength in a mouse decision-making task.
  • Emphasis on cross-modal, multi-scale data integration and on-demand pipeline generation rather than fixed, hand-built analysis workflows.
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