🛰️ Daily AI Frontier
‹ back to 2026-08-05

DCAF11-dependent molecular glue degrader activated by glutathionylation

Research Bioinformatics AI

Ranking

Overall 82
Content 90
Popularity 62

Observed public metrics from 1 member.

Merged summary

TL;DR - M12 is a metabolically activated molecular glue that directs diverse proteins to DCAF11 for ubiquitin-mediated degradation. Its glutathione-dependent activation could broaden targeted protein degradation to more substrates.

  • Glutathionylation activates M12’s degrader activity.
  • M12 recruits multiple protein substrates to the DCAF11 ubiquitin ligase.
  • Recruited proteins undergo ubiquitin-mediated degradation.
  • The mechanism expands the potential scope of molecular-glue therapeutics.

Sources (1)

DCAF11-dependent molecular glue degrader activated by glutathionylation

Nature Hojong Yoon, Franziska Wachter, Katharine A. Barrett, Cyrus Jin, Anna Rodríguez-Pöhnlein, Justine C. Rutter, Ryan J. Lumpkin, Rebecca J. Metivier, Katherine A. Donovan, Kheewoong Baek, Yongying Jiang, Minwoo Lee, Robert W. Kalis, Jianwei Che, Yuan Xiong, Eric S. Fischer, Benjamin L. Ebert 2026-08-05 doi:10.1038/s41586-026-10873-1
Public signals OpenAlex citations 1
Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-03 14:32:16.015317 UTC

TL;DR - M12 is a metabolically activated molecular glue that directs diverse proteins to DCAF11 for ubiquitin-mediated degradation. Its glutathione-dependent activation could broaden targeted protein degradation to more substrates.

  • Glutathionylation activates M12’s degrader activity.
  • M12 recruits multiple protein substrates to the DCAF11 ubiquitin ligase.
  • Recruited proteins undergo ubiquitin-mediated degradation.
  • The mechanism expands the potential scope of molecular-glue therapeutics.
item →