Nature Methods
James Joly, Vivekananda Budamagunta, Zhengjian Zhang, Brittany Nortman, Maryam Jouzi, Rajat Bhatnagar, Jarrett D. Egertson, Michael E. Flaster, Rob Grothe, Sanjib Guha, Kota Kaneshige, Kevin McVey, Nicholas Nelson, Rukshan T. Perera, Steven J. Tan, Tuan Trinh, David Arnott, Joanna Lipka, Nikhil J. Pandya, Lionel Rougé, Timothy J. Wendorff, Donald S. Kirkpatrick, Alexis Rohou, David C. Butler, Steven Lotz, Ana Forton, Emily R. Sartori, Jessica E. Schwarz, Phillip S. Brereton, Kevin Chen, Michael A. Darcy, Hamid R. Golnabi, Ross Hartley, Pierre F. Indermuhl, Christina E. Inman, Kevin M. Jin, Stanislav Katsyuk, Rajesh Kota, Bryant Lowry, Jonathan C. Menger, Denise A. Miller, Maureen R. Newman, Adedeji Ogunyemi, Julia K. Robinson, Noah Steiner, Juanfeng Sun, Scott M. Tabakman, Lisen Wang, Zhiqiang Wang, Sheri K. Wilcox, Jamie E. Anderson, Fletcher Bain, Filip Bartnicki, Issa Beekun, Giovanni Bellesia, Rajat Bhatnagar, Keith Bjornson, Phillip S. Brereton, Stephen Brown, Vivekananda Budamagunta, Kaitlyn Burke, Chieh-Li Chen, Kevin Chen, Priscilla L. Chen, Krista Cosert, Danya Cruver, Michael A. Darcy, Wade Dugdale, Ahana Dutta, Jarrett D. Egertson, Michael E. Flaster, Tyler J. Ford, Keith Frankie, Taryn E. Gillies, Keith Gneshin, Hamid R. Golnabi, Sam Grillo, Rob Grothe, Cynthia Y. Guerrero, Pengyu Hao, Ross Hartley, Brooks D. Hoehn Jr., Martin Huber, Andreas F. R. Huhmer, Christina E. Inman, James Joly, Kevin M. Jin, Maryam Jouzi, Kara Juneau, Gregory T. Kapp, Kota Kaneshige, Stanislav Katsyuk, Eun Kim, Rajesh Kota, Jamie Rose Kuhar, Jonathan B. Leano, Darrel Lee, Winnie Leung, Cara Li, Bryant Lowry, Parag Mallick, Mara Manskie, Carlos F. Martinez, Kevin McVey, Jonathan C. Menger, Denise A. Miller, Eva Monsen, Anna Mowry, Grant Napier, Nicholas Nelson, Nicole Newland, Maureen R. Newman, Brittany Nortman, Adedeji Ogunyemi, Jayetha Panakkadan, Sujal Patel, Rukshan T. Perera, Nguyen Pham, Keshav Prabhu, Maximilian O. Press, Hongji Qian, Torri E. Rinker, Adam J. Roberts, Julia K. Robinson, Aimee A. Sanford, Ali Najafi Sohi, Subramanian V. Sankar, Parag Shekher, Genee Victoria Skulich, Irene Tang Sparck, Isaac B. Sprague, Noah Steiner, Robert Stephenson, Juanfeng Sun, Kentaro Suzuki, Scott M. Tabakman, Steven J. Tan, Nicholas Tardif, Sonal S. Tonapi, Jasmine Trinh, Tuan Trinh, Maria Villancio-Wolter, Jacinto Villanueva, Lisen Wang, Zhiqiang Wang, Gwen Weld, Sheri K. Wilcox, Katherine Winters, Feng Yan, Yvonne Yeung, Zhengjian Zhang, Gregory T. Kapp, Sujal Patel, Sally Temple, Taylor Bertucci, Joel Blanchard, Andreas F. R. Huhmer, Subramanian V. Sankar, Kara Juneau, Parag Mallick
2026-09-04
doi:10.1038/s41592-026-03188-6
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TL;DR - This Nature Methods paper introduces Iterative Mapping of proteoforms, a method for large-scale measurement of intact proteoforms at single-molecule resolution. It could improve analysis of tau’s molecular diversity in tauopathy models and human brain tissue.
- Measures intact proteoform groups rather than only isolated peptides or aggregate protein abundance.
- Demonstrates the approach on control samples with known composition.
- Applies the method to tauopathy research models and human-derived brain tissue.
- Enables quantitative study of tau proteoform heterogeneity across experimental and biological samples.