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A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Research Medical/Healthcare AI

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TL;DR - A Nature study identifies a serpin–myeloid mechanism that contributes to heterogeneity and immune evasion in pancreatic ductal carcinoma. SERPINE1 and SERPINB2 create localized, fibrin-rich niches that promote immunosuppressive macrophages and T-cell exclusion.

  • The mechanism links serpin activity to spatially organized immune suppression within pancreatic tumors.
  • Fibrin-rich niches locally program macrophages toward an immunosuppressive state.
  • These niches exclude T cells, potentially helping tumors evade antitumor immunity.
  • The findings highlight the serpin–myeloid axis as a potential therapeutic target in pancreatic cancer.

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A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature Chiara Falcomatà, Maximilian M. Schaefer, Bhavya Singh, Divya Chhamalwan, Alexander Tepper, Sebastian R. Nielsen, Hunter T. Potak, Maxime Dhainaut, Gurkan Mollaoglu, Matthew D. Park, Miriam Merad, Alessia Baccarini, Brian D. Brown 2026-09-09 doi:10.1038/s41586-026-11002-8
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:20:29.281077 UTC

TL;DR - A Nature study identifies a serpin–myeloid mechanism that contributes to heterogeneity and immune evasion in pancreatic ductal carcinoma. SERPINE1 and SERPINB2 create localized, fibrin-rich niches that promote immunosuppressive macrophages and T-cell exclusion.

  • The mechanism links serpin activity to spatially organized immune suppression within pancreatic tumors.
  • Fibrin-rich niches locally program macrophages toward an immunosuppressive state.
  • These niches exclude T cells, potentially helping tumors evade antitumor immunity.
  • The findings highlight the serpin–myeloid axis as a potential therapeutic target in pancreatic cancer.
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