Tumour cells shape their environment to protect them from the immune system
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TL;DR - A subset of pancreatic cancer cells builds a sticky molecular matrix that shields tumours from immune attack. Disrupting this process improved immune control and sensitivity to immunotherapy in mice.
- Cancer cells expressing SERPINE1 or SERPINB2 form a protective molecular mesh around themselves.
- The matrix retains immunosuppressive cells while excluding immune cells capable of killing cancer cells.
- Targeting this mechanism could help overcome immune resistance in pancreatic tumours.
- The reported therapeutic evidence is preclinical and based on mouse models.
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Tumour cells shape their environment to protect them from the immune system
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TL;DR - A subset of pancreatic cancer cells builds a sticky molecular matrix that shields tumours from immune attack. Disrupting this process improved immune control and sensitivity to immunotherapy in mice.
- Cancer cells expressing SERPINE1 or SERPINB2 form a protective molecular mesh around themselves.
- The matrix retains immunosuppressive cells while excluding immune cells capable of killing cancer cells.
- Targeting this mechanism could help overcome immune resistance in pancreatic tumours.
- The reported therapeutic evidence is preclinical and based on mouse models.