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Lsp2 links early-life diet to adult translation and lifespan in Drosophila

Research Metabolism & Longevity

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TL;DR - A Drosophila study uses isotope tracing to connect larval amino-acid intake with adult protein translation and lifespan. It identifies Lsp2 as a key molecular mediator of the lasting effects of early-life protein restriction.

  • Traces the fate of amino acids consumed during larval development into adulthood.
  • Links early-life diet to long-term regulation of protein translation.
  • Identifies Lsp2 as a central regulator connecting developmental nutrition with adult lifespan.
  • Provides a molecular basis for how early protein restriction can have persistent physiological effects.

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Lsp2 links early-life diet to adult translation and lifespan in Drosophila

Nature Hina Kosakamoto, Rina Okada, Clive S. Barker, Ayako Isomura-Matoba, Jun Seita, Naoshi Dohmae, Koshi Imami, Fumiaki Obata 2026-09-23 doi:10.1038/s41586-026-11031-3
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-26 14:13:58.315369 UTC

TL;DR - A Drosophila study uses isotope tracing to connect larval amino-acid intake with adult protein translation and lifespan. It identifies Lsp2 as a key molecular mediator of the lasting effects of early-life protein restriction.

  • Traces the fate of amino acids consumed during larval development into adulthood.
  • Links early-life diet to long-term regulation of protein translation.
  • Identifies Lsp2 as a central regulator connecting developmental nutrition with adult lifespan.
  • Provides a molecular basis for how early protein restriction can have persistent physiological effects.
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