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The mutational dynamics of the Arabidopsis centromeres

Research Bioinformatics AI

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TL;DR - A Nature study finds that Arabidopsis centromeres evolve through frequent repeat-unit insertions and deletions, alongside elevated point mutations driven by homology-directed repair. This mutation spectrum may explain how large, homogenized tandem-repeat blocks arise and persist.

  • Examines mutational dynamics in the centromeres of Arabidopsis thaliana.
  • Identifies frequent insertions and deletions involving repeat units.
  • Links increased point-mutation rates to homology-directed repair.
  • Shows that these processes are sufficient to generate and maintain homogenized centromeric repeat arrays.

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The mutational dynamics of the Arabidopsis centromeres

Nature Xiao Dong, Wen-Biao Jiao, Lara Goldkuhle, Fernando Rabanal, Samija Amar, Matthew T. Parker, José A. Campoy, Yueqi Tao, Bruno Huettel, Jurriaan Ton, Lisa M. Smith, Holger Puchta, Detlef Weigel, Korbinian Schneeberger 2026-09-23 doi:10.1038/s41586-026-11046-w
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-26 14:04:50.559524 UTC

TL;DR - A Nature study finds that Arabidopsis centromeres evolve through frequent repeat-unit insertions and deletions, alongside elevated point mutations driven by homology-directed repair. This mutation spectrum may explain how large, homogenized tandem-repeat blocks arise and persist.

  • Examines mutational dynamics in the centromeres of Arabidopsis thaliana.
  • Identifies frequent insertions and deletions involving repeat units.
  • Links increased point-mutation rates to homology-directed repair.
  • Shows that these processes are sufficient to generate and maintain homogenized centromeric repeat arrays.
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