看下Cell杂志的成纤维细胞亚群的分类大法：又长见识了！

TL;DR - This technical walkthrough revisits a 2019 Cell single-cell atlas of ulcerative colitis, explaining how colon fibroblasts were divided into eight spatial and functional subtypes. The classification links inflammatory fibroblasts and OSM–OSMR signaling to disease pathology and anti-TNF resistance.

• The study profiled 366,650 cells from 68 biopsies across 18 ulcerative-colitis patients and 12 healthy controls.
• Fibroblasts were organized along the crypt–villus axis using WNT/BMP programs, including WNT2B⁺ crypt-associated and WNT5B⁺ villus-associated populations.
• UC-specific inflammatory fibroblasts expressed IL13RA2, IL11, OSMR, FAP, and matrix-remodeling genes, distinguishing them from contractile myofibroblasts.
• The article provides Seurat code and public SCP259 data for reproducing fibroblast extraction, clustering, and marker visualization.