看下Cell杂志的成纤维细胞亚群的分类大法：又长见识了！
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TL;DR - This technical walkthrough revisits a 2019 Cell single-cell atlas of ulcerative colitis, explaining how colon fibroblasts were divided into eight spatial and functional subtypes. The classification links inflammatory fibroblasts and OSM–OSMR signaling to disease pathology and anti-TNF resistance.
- The study profiled 366,650 cells from 68 biopsies across 18 ulcerative-colitis patients and 12 healthy controls.
- Fibroblasts were organized along the crypt–villus axis using WNT/BMP programs, including WNT2B⁺ crypt-associated and WNT5B⁺ villus-associated populations.
- UC-specific inflammatory fibroblasts expressed IL13RA2, IL11, OSMR, FAP, and matrix-remodeling genes, distinguishing them from contractile myofibroblasts.
- The article provides Seurat code and public SCP259 data for reproducing fibroblast extraction, clustering, and marker visualization.
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看下Cell杂志的成纤维细胞亚群的分类大法：又长见识了！
Public signals
N/A
TL;DR - This technical walkthrough revisits a 2019 Cell single-cell atlas of ulcerative colitis, explaining how colon fibroblasts were divided into eight spatial and functional subtypes. The classification links inflammatory fibroblasts and OSM–OSMR signaling to disease pathology and anti-TNF resistance.
- The study profiled 366,650 cells from 68 biopsies across 18 ulcerative-colitis patients and 12 healthy controls.
- Fibroblasts were organized along the crypt–villus axis using WNT/BMP programs, including WNT2B⁺ crypt-associated and WNT5B⁺ villus-associated populations.
- UC-specific inflammatory fibroblasts expressed IL13RA2, IL11, OSMR, FAP, and matrix-remodeling genes, distinguishing them from contractile myofibroblasts.
- The article provides Seurat code and public SCP259 data for reproducing fibroblast extraction, clustering, and marker visualization.