Stimulation modulates gene-linked cell assemblies in the human brain

TL;DR - This Nature study presents an ex vivo human-cortex framework showing that stimulation reorganizes neural cell assemblies and activates cell-type-specific gene-regulatory programs. It could inform more precisely targeted neuromodulatory therapies.

• Links stimulation parameters to both circuit-level and transcriptional responses.
• Identifies gene-linked neural assemblies that change with cortical stimulation.
• Reveals cell-type-specific regulatory responses to stimulation.
• Provides a platform for designing targeted neuromodulation strategies.