Stimulation modulates gene-linked cell assemblies in the human brain
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TL;DR - This Nature study presents an ex vivo human-cortex framework showing that stimulation reorganizes neural cell assemblies and activates cell-type-specific gene-regulatory programs. It could inform more precisely targeted neuromodulatory therapies.
- Links stimulation parameters to both circuit-level and transcriptional responses.
- Identifies gene-linked neural assemblies that change with cortical stimulation.
- Reveals cell-type-specific regulatory responses to stimulation.
- Provides a platform for designing targeted neuromodulation strategies.
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Stimulation modulates gene-linked cell assemblies in the human brain
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TL;DR - This Nature study presents an ex vivo human-cortex framework showing that stimulation reorganizes neural cell assemblies and activates cell-type-specific gene-regulatory programs. It could inform more precisely targeted neuromodulatory therapies.
- Links stimulation parameters to both circuit-level and transcriptional responses.
- Identifies gene-linked neural assemblies that change with cortical stimulation.
- Reveals cell-type-specific regulatory responses to stimulation.
- Provides a platform for designing targeted neuromodulation strategies.