Nature：重要性超乎想象，全面揭示母亲对婴儿肠道微生物组及其健康的影响

TL;DR - A Nature study of 714 mother–infant pairs finds that maternal gut microbes are the primary source of infants’ gut microbiomes, with early microbial development potentially affecting later health.

• Researchers analyzed 4,526 longitudinal stool samples using metagenomic sequencing and integrated 474 clinical and exposure variables.
• Delivery and feeding methods strongly shaped infant microbial composition and functions, including carbohydrate metabolism.
• Maternal gut-to-infant transmission was common, whereas transmission from breast milk and the reproductive tract was rare.
• Maternal microbiome characteristics were associated with infant eczema, suggesting links between maternal microbial health and childhood outcomes.