Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

TL;DR - A Nature study reports that restoring Meis2 expression in hippocampal parvalbumin interneurons rescues neural plasticity and cognitive function in an adult mouse model of neurodevelopmental disorders.

• Meis2 restoration improved experience-dependent plasticity.
• Treated mice showed better memory and neural network function.
• The intervention also suppressed seizures, suggesting adult neural dysfunction may remain reversible.