Cancer Cell：骨髓中存在潜伏的抗肿瘤T细胞

TL;DR - A Cancer Cell study identifies latent, tumor-reactive T cells in the bone marrow of multiple myeloma and acute myeloid leukemia patients. These cells can be activated by immunotherapy, offering a framework for predicting and improving treatment responses.

• Integrated TCR profiling, HLA immunopeptidomics, and functional single-cell screening revealed a conserved effector program distinct from exhausted T cells in solid tumors.
• Partially shared, noncanonical immunopeptides drove convergent TCR responses across both malignancies.
• The TFiT transcriptional classifier identified tumor-reactive bone-marrow T cells and stratified immunotherapy—but not chemotherapy—responses in independent cohorts.
• The findings suggest endogenous antitumor immunity in bone marrow can be mobilized therapeutically.