Human brain stimulation engages different gene programs in different cell types

TL;DR - Human temporal-cortex stimulation activates distinct gene programs across different cell types alongside neuronal-network activity. Understanding these responses could guide stimulation-based therapies for slowing cognitive decline.

• Electrical brain stimulation is being explored as a strategy against cognitive deterioration.
• Stimulation-induced molecular responses vary by cell type.
• The gene programs occur in tandem with temporal-cortex neuronal-network activity.
• These findings could inform more targeted therapeutic stimulation approaches.